Dermatological toxicity of acute lymphoblastic leukemia treatment by protocol ALL IC-BFM 2002
نویسندگان
چکیده
Background. Аcute lymphoblastic leukemia (ALL) in children is not only the most common but also potentially curable disease 8590% cases. The other side of high effectiveness modern treatment protocols their toxicity. Inspite skin and mucosal toxicity a life threatening condition, it requires supportive care to prevent infectious complications, which prolong hospitalization, administration antibacterial, antifungal some cases antiviral drugs.
 Aim. To study patients with ALL, treated by ALL IC-BFM 2002 protocol.
 Materials methods. One hundred nineteen pediatric primary diagnosed were enrolled study. All protocol. Toxicity assessment was performed on each step scale National Cancer Institute (NCI) USA, 2d version.
 Results. often variants during protocol found mM/M, based high-dosed methotrexate. In 42.1% stomatitis 2st. methotrexate dose 5000 mg/m2, 3st. 15.8%, 4st. 5,3%. Methotrexate dosed 2000 mg/m2 coused 3 st. 6.3%, 12st. Exfoliative dermatitis 1 (1%) case prolonged elimination. Block polychemotherapy used risk group complicated 34 90%. 20% naso-gastral catheter 25% partial/hole parenteral nutrition support. Alopecia reversible observed 100% patients. Protocols I, II maintenance free clinically significant toxicity.
 Conclusion. profile tolerable. Hole volume care, preventing dermatological chemotherapy can severe (soft tissue infections, sepsis, metabolic disorders).
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ژورنال
عنوان ژورنال: Consilium medicum
سال: 2022
ISSN: ['2075-1753', '2542-2170']
DOI: https://doi.org/10.26442/20751753.2022.6.201689